![]() 3 Multiple proposed mechanisms behind the increased incidence of thrombosis include a prothrombotic state in conjunction with platelet abnormalities and impaired fibrinolysis. 2 Despite such a large role in the burden of the disease, the mechanism behind the development of thrombosis is poorly understood, highlighting the importance of thrombosis management in PNH patients and elucidating more information regarding the nature of the thrombotic event. 1 Thromboembolic events are the most common cause of morbidity and mortality in PNH and account for 40–67% of deaths 40% of patients having suffered an event before diagnosis and 29–44% of patients suffering at least one event throughout the course of their disease. It is caused by an acquired mutation in the X-linked phosphatidylinositol glycan class A gene ( PIG-A), causing stem cell progeny (mature blood cells) to lack complement regulatory proteins and exposing them to complement attack. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder of multipotent hematopoietic stem cells. Further studies, including novel in vivo and in vitro thrombosis models, are required in order to define the role of the individual mechanisms contributing to thrombosis, impaired fibrinolysis and clarify other complement-driven prothrombotic mechanisms in paroxysmal nocturnal hemoglobinuria. While many factors may affect thrombosis in paroxysmal nocturnal hemoglobinuria, the relative contribution of each mechanism that has been implicated is difficult to quantify. Impaired fibrinolysis has also been observed and may be caused by several mechanisms involving interactions between complement activation, coagulation and fibrinolysis. Platelet and endothelial microparticles as well as oxidative stress may play a role. ![]() Paroxysmal nocturnal hemoglobinuria leads to a complex and multifaceted prothrombotic state due to the pathological effects of platelet activation, intravascular hemolysis and neutrophil/monocyte activation. ![]() This review article discusses the different factors that contribute to the increased risk of thrombosis in paroxysmal nocturnal hemoglobinuria. The increased incidence of thrombosis in paroxysmal nocturnal hemoglobinuria is still poorly understood, but unlike many other thrombotic disorders, predominantly involves complement-mediated mechanisms. Paroxysmal nocturnal hemoglobinuria is a rare acquired hematologic disorder, the most serious complication of which is thrombosis.
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![]() Complete with AMD Ryzen™ processors and AMD Radeon™ graphics, the Lenovo Legion 7 and the Lenovo Legion Slim 7 offer greater freedom to roam, while still retaining the power and performance to support so its users can continue to be irrepressibly stylish on the outside, and indomitably savage on the inside. Lenovo Legion laptops serve as an epic conduit, bridging the worlds that gamers often straddle. Lenovo has teamed up with comic artist and game designer Salva Espín, to create a collection of limited-edition stickers that combine the on and offline world. Whereas those working in the computer sector feel most authentic playing RPGs (45%) with creatives (40%) opting for role playing games. According to Lenovo’s research study, clerical workers (44%), medical & healthcare workers (42%), financial workers (38%) and science workers (40%) for example, feel their most authentic self when playing strategic games. With nearly 60% of gamers choosing to keep their gaming life until after work, findings revealed that certain professions feel their most authentic when playing specific genres of games. The digital world truly is a matrix of the real world, as research conducted by Lenovo found gamers feel their most authentic self when gaming at home (58%), followed by socialising with friends and family (52%) and participating in other personal hobbies and interests (46%). Comic artist and game designer, Salva Espín Inspired by this dual-persona, Lenovo has teamed up with comic artist and game designer Salva Espín, to create a collection of limited-edition stickers that combine the on and offline world. Janu– New research¹ has today revealed that over half (52%) of gamers identify with their online alter-ego more than their real-life identity. To celebrate these dual-personas, Lenovo has partnered with renowned Marvel comic artist and game designer, Salva Espín, to design five Lenovo Legion ‘Second Skin’ stickers that capture this duality – and you can design the final sticker ![]() ![]() Strong and flavorful, the Amnesia Haze strain is paraded by purists and veterans for delivering an experience that encapsulates classic cannabis. Thick in flavor and strong with aroma, the concentrates made from the Amnesia Haze strain maximize the entourage effect of cannabis and give you the complete effects of the herb without compromising flavor. Its potent chemistry creates excellent extracts that are rich with the various cannabinoids that make cannabis and effective herb. If you were hoping to use the Amnesia Haze strain as a foundation for cannabis-derived products, its complex trichome profile makes it a good pick. Any shorter than that, and you’re likely to dampen the strain’s potency. Relative to other strains, the Amnesia Haze cultivar takes a little longer to reach full maturity, requiring a full 12 weeks before they’re ripe for harvest. The high-yield herb grows a modest height of around 6 feet, producing 6 ounces of bud per foot of its growth. Moderately difficult to grow, the Amensia Haze strain is best suited to cultivators who have previous experience in the process. Awakening the kraken from within, this strain should never be used without a pantry-full of food to keep your stomach at bay throughout the munchies. True enough, the ‘Amnesia’ in the strain’s name comes from the fact that it can ease away your worries and stress.Īside from the feeling of well-being and happiness, Amnesia Haze can get your tummy grumbling. Just like the other classics of the cannabis market, Amnesia Haze is beloved for its capability to inspire a smiley disposition, giving you an episode of giggles that you might not have experienced with more common, contemporary strains. What’s particularly satisfying is the way that it unleashes an unrelenting sense of well-being and happiness. With your body in full submission, the strain releases a whirlwind of cognitive awakening. The body-centric effects first make the limbs feel limp, causing them to fall at your sides and making you feel inclined to take a load off. The effects are slow to start, but the gradual, change makes the entire experience pleasant, steady, and easy to cope with. Once the strain gets your attention with its heavy-handed flavor, it goes to work on your system. This blend of soil and citrus awakens the senses and brings with it a powerful punch of alertness to revive your tired spirits. The strain kicks off the experience with its strong earthy, lemon-laced flavor that perfectly replicates the cultivar’s nose. Whether you’ve been feeling down in the dumps, or if you’re simply looking for a solution against that lack of energy, the Amnesia Haze strain can be the ideal answer. But more than their contribution to aesthetic, these trichomes shed light on the strain’s complex CBD profile and its potent effects. The dense coat produces makes the nugs glisten in the light, and dazzles with sparkling appeal. As though dipped in a confectioner’s pot of sugar, the Amnesia Haze strain touts a glorious blanket of trichomes. After all, it’s not named ‘Haze’ for nothing. In terms of its look, the Amnesia Haze strain isn’t that hard to tell apart from a line-up. The juxtaposition of elements battle out for supremacy and tug at the nostrils with their equally potent presence. Strong earthy undertones create a cradle of flavor, embracing the soft, gentle aroma of lemon and citrus that takes center stage. The Amnesia Haze strain’s nose is complex and intricate, leading you on a sensory journey that’s guaranteed to awaken your system. Altogether, their combination resulted in a sativa-leaning Amnesia Haze that lends hints of relaxation as an homage to its South Asian parent. The former is a heavyweight indica strain, and the latter, potent sativa. ![]() Born from two land races, the Amnesia Haze cultivar demonstrates the glorious genetics of the South Asian and Jamaican native herbs. The origins of the strain shed light on the kind of untouched chemistry behind its leaves. This 80’s cultivar is often considered one of the classics, and is enjoyed by veterans and purists who want to experience the effects of a true blue, award-winning sativa strain. The Amnesia Haze strain first came on to the cannabis scene during the herb’s prime era. And just like the name suggests, this cultivar can make you forget all of the worries of everyday life with its lemon flavored haze. Its effects take you on a trip of mellow relaxation that can have you smiling and giggling for hours on end. Bringing together the blinding genetics of two parent land races, this cultivar is a top performer, having bagged two golds at the Cannabis Cup. Popular in the world’s cannabis capital – Amesterdam – Amnesia Haze is the purist’s dream. With a name like Amnesia Haze, this strain tells pretty much already tells you what you’re in for once you take a drag. Industrial Hemp Farms FebruBlog Comments Off on Amnesia Haze Cannabis Strain Review ![]() Huffman went on to co-found Hipmunk with Adam Goldstein, and later recruited Ohanian and Slowe to the new company. In January 2007, Swartz was fired for undisclosed reasons. In November 2006, Swartz blogged complaining about the new corporate environment, criticizing its level of productivity. Huffman and Ohanian sold Reddit to Condé Nast Publications, owner of Wired, on October 31, 2006, for a reported $10 million to $20 million and the team moved to San Francisco. Ohanian later wrote that instead of labeling Swartz as a co-founder, the correct description is that Swartz's company was acquired by Reddit 6 months after he and Huffman had started. Between November 2005 and January 2006, Reddit merged with Aaron Swartz's company Infogami, and Swartz became an equal owner of the resulting parent company, Not A Bug. The team expanded to include Christopher Slowe in November 2005. Embarrassed by an empty-looking site, the founders created hundreds of fake users for their posts to make it look more populated, an example of a fake it till you make it strategy. Supported by the funding from Y Combinator, Huffman coded the site in Common Lisp and together with Ohanian launched Reddit in June 2005. For this idea, Huffman and Ohanian were accepted in Y Combinator's first class. During a brainstorming session to pitch another startup, the idea was created for what Graham called the "front page of the Internet". Their initial idea, My Mobile Menu, was unsuccessful, and was intended to allow users to order food by SMS text messaging. After speaking with Huffman and Ohanian following the lecture, Graham invited the two to apply to his startup incubator Y Combinator. The idea and initial development of Reddit originated with college roommates Steve Huffman and Alexis Ohanian in 2005, who attended a lecture by programmer-entrepreneur Paul Graham in Boston, Massachusetts, during their spring break from University of Virginia. Co-founder Alexis Ohanian speaking in 2009 Reddit's headquarters in the Mid-Market neighborhood of San Francisco Historyįor a chronological guide, see Timeline of Reddit. Reddit has drawn negative attention for its propensity to spread potentially dangerous misinformation. Reddit has received praise for many of its features, such as the ability to create several subreddits for niche communities, being a platform for raising publicity for numerous causes, and has grown to be one of the most visited websites on the Internet. The company then reportedly filed for an IPO in December 2021 with a valuation of $15 billion. In August 2021, a $700 million funding round led by Fidelity Investments raised that valuation to over $10 billion. In February 2019, a $300 million funding round led by Tencent brought the company's valuation to $3 billion. In July 2017, Reddit raised $200 million for a $1.8 billion valuation, with Advance Publications remaining the majority stakeholder. Their investment valued the company at $500 million at the time. In October 2014, Reddit raised $50 million in a funding round led by Sam Altman and including investors Marc Andreessen, Peter Thiel, Ron Conway, Snoop Dogg, and Jared Leto. In 2011, Reddit became an independent subsidiary of Condé Nast's parent company, Advance Publications. Condé Nast Publications acquired the site in October 2006. Reddit was founded by University of Virginia roommates Steve Huffman and Alexis Ohanian, with Aaron Swartz, in 2005. According to data provided by Similarweb, 48.98% of the websites traffic comes from the United States followed by the United Kingdom at 7.06% and Canada at 6.9%. Īs of October 2023, Reddit is the 18th most-visited website in the world. ![]() It is operated by Reddit Inc., based in San Francisco. ![]() ![]() Moderation is also conducted by community-specific moderators, who are not Reddit employees. Reddit administrators moderate the communities. Submissions with more upvotes appear towards the top of their subreddit and, if they receive enough upvotes, ultimately on the site's front page. Posts are organized by subject into user-created boards called "communities" or "subreddits". Registered users (commonly referred to as "redditors") submit content to the site such as links, text posts, images, and videos, which are then voted up or down by other members. Reddit ( / ˈ r ɛ d ɪ t/) is an American social news aggregation, content rating, and discussion website. ![]() If you would like to comeback to our category sport overview, please visit our Vipbox menu schedule. We recommend starting from the first links on Vipbox, because the streams are sorted according to the best ones. All you have to do is click on the event you are currently looking to watch and then select the appropriate match link under which the stream link is hidden. In any case, the process of getting a live currently broadcast of a match as a Vipbox Streams user is very simple. You will find the best Vip TV Box streams from link number 1 Just click on our Vip Box soccer category. This popular sport, specially in Europe, you can find on Vipbox website schedule also. You will not miss also classic football or soccer. Furthermore, of course, the National Hockey League (NHL) or the National Basketball Association (NBA), which is the imaginary peak of Mount Olympus in the basketball world.Īll football or soccer leagues live online on Vipbox TV Streaming channel Thanks for watching on VIPRow, and remember to bookmark us VIP Box Sports - Watch live free sport from the Premier League, live football streaming, Live NFL NBA, MLB, NHL streaming only. It was called The Thrilla in Manila which Ali won in 1975. One of the most famous Boxing bouts ever. Of course, fans of classic US Sports, such as the most prestigious National Football League (NFL), the best competition in the world of American Football, will also come to their senses. In game 5 of the 1956 World Series Don Larsen made magic. ![]() Vip Box focuses mainly on streaming US Sports Whether for team or individual sports, including races for all possible motorsports or fights of any combat sports tournament from UFC to Boxing show evenings. Here, every visitor to Vipbox TV will see events, which are chronologically sorted according to time. ![]() The best streaming overview Vipbox webpage So that you don't have to search for your match through the individual categories of sports, just open our VIP Box complete overview. Vipbox brings online and all day updated webpage that contains all the sports and categories that exist in one place. ![]() Used Prompter People Ultralight iPad/Android Teleprompter for Any iPAD/Android Tablets E CONDITION: E. A Video Editor : capture multiple video takes & choose the best. Details Autocue Starter Series iPad Pro 12.9 package (excludes iPad Pro) A complete hardware package that turns your iPad Pro 12.9 not included into a. 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Bluetooth Teleprompter Remote for Ikan Teleprompters. The Elite Pro is a 15mm rod-based system, equipped with a raised, quick-release camera platform above the rods, and with a tripod-mount platform underneath the rods.Īn Elite Remote Control designed for use specifically with iPads is included. Ikan PT-Elite-PRO Elite Universal Large Tablet for Surface Pro & iPad Pro Teleprompter (Black) 4. Elite-Remote iPad & Tablet Teleprompters. ![]() The Elite Pro has a more flexible design than the original Elite prompter, featuring an adjustable/foldable glass frame and quick-release camera platform. The ikan Elite Pro has all the same features as the Elite V2, but instead of a standard tablet mount, it includes a larger mount supporting the iPad Pro, Surface Pro, and all other tablets ranging from 6 x 9 to 9 x 12" in size. iPad / Small Teleprompter Teleprompter Pal Teleprompter Pal FREESTANDING Teleprompter Pal - 15MM Prompter People Ultralight IPad 10 Teleprompter Prompter. 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![]() Assuredly, I say to you, wherever this gospel is preached in the whole world, what this woman has done will also be told as a memorial to her.”Ī. For in pouring this fragrant oil on My body, she did it for My burial. For you have the poor with you always, but Me you do not have always. But when His disciples saw it, they were indignant, saying, “Why this waste? For this fragrant oil might have been sold for much and given to the poor.” But when Jesus was aware of it, He said to them, “Why do you trouble the woman? For she has done a good work for Me. ![]() (6-13) A woman anoints Jesus before His death.Īnd when Jesus was in Bethany at the house of Simon the leper, a woman came to Him having an alabaster flask of very costly fragrant oil, and she poured it on His head as He sat at the table. Jerusalem’s population swelled perhaps fivefold during the feast and with religious fervor and national messianism at a high pitch, a spark might set off an explosion.” (Carson) 3. “The leaders were right in fearing the people. This is another subtle indication that Jesus was in control of events, as they in fact killed Him on the very day that they didn’t want to. ![]() Not during the feast, lest there be an uproar: They didn’t want to put Jesus to death during Passover, but that is exactly how it happened. Caiaphas, unable to bear this disgrace, and the stings of his conscience for the murder of Christ, killed himself about A.D. “About two years after our Lord’s crucifixion, Caiaphas and Pilate were both deposed by Vitellius, then governor of Syria, and afterwards emperor. This was an extraordinarily long time for a High Priest to last, and Caiaphas must have brought the technique of co-operating with the Romans to a fine art.” (Barclay) The suggestive thing is that Caiaphas was High Priest from A.D. 67… there were no fewer than twenty-eight High Priests. Doubtless some continued to call either man ‘high priest.’” (Carson) But since according to the Old Testament the high priest was not to be replaced till after his death, the transfer of power was illegal. 15 and replaced by Caiaphas, who lived and ruled till his death in A.D. The high priest, who was called Caiaphas: “Annas was deposed by the secular authorities in A.D. According to Carson, the use of both assembled and plotted is deliberately suggestive of Psalm 31:13: For I am the slander of many fear is on every side while they take counsel together against me, they scheme to take away my life. ![]() Then the chief priests, the scribes, and the elders… plotted to take Jesus by trickery and kill Him: The long controversy between Jesus and the religious leaders had finally come to this. But they said, “Not during the feast, lest there be an uproar among the people.”Ī. Then the chief priests, the scribes, and the elders of the people assembled at the palace of the high priest, who was called Caiaphas, and plotted to take Jesus by trickery and kill Him. Jesus reminded them that this was not the case. You know that after two days…the Son of Man will be delivered up to be crucified: Perhaps after the triumphal descriptions of the coming kingdom, the disciples were strengthened in their idea that it was impossible that the Messiah should suffer. “Having instructed his disciples and the Jews by his discourses, edified them by his example, convinced them by his miracles, he now prepares to redeem them by his blood!” (Clarke)ī. Now, it was time for Jesus to fulfill His work on the cross. In these last days leading up to His betrayal and crucifixion, He warned the multitudes about the corrupt religious leadership and He spoke to His disciples about things to come. When Jesus had finished all these sayings: In Matthew’s Gospel, the teaching of Jesus is finished here. Now it came to pass, when Jesus had finished all these sayings, that He said to His disciples, “You know that after two days is the Passover, and the Son of Man will be delivered up to be crucified.”Ī. (1-2) Jesus reminds His disciples of His coming suffering and crucifixion. The stage is set for the arrest and crucifixion of Jesus. ![]() The best means of preventing early fatigue of wire ropes is to use sheaves and drums of adequate size. ![]() The effect of fatigue on wires is illustrated by bending a wire repeatedly back and forth until it breaks. The repeated bending of the individual wires, as the rope bends when passing over the sheaves or drums, and the straightening of the individual wires, as the rope leaves the sheaves or drums, causing fatigue. It occurs when ropes operate over comparatively small sheaves or drums. The proper safety factor depends not only on the loads applied, but also on the speed of operation, shock load applied, the type of fittings used for securing the rope ends, the acceleration and deceleration, the length of rope, the number, size and location of sheaves and drums, the factors causing abrasion and corrosion and the facilities for inspection.įatigue Fatigue failure of the wires in a wire rope is the result of the propagation of small cracks under repeated applications of bending loads. It is not possible to set safety factors for the various types of wire rope using equipment, as this factor can vary with conditions on individual units of equipment. A wire rope with a strength of 10,000 pounds and a total working load of 2,000 pounds would be operating with a safety factor of five. Safety Factors The safety factor is the ratio of the strength of the rope to the working load. As the strength of a wire rope is determined by its, size, grade and construction, these three factors should be considered. For the most part, these stresses can be converted into terms of simple tension, and a rope of approximately the correct strength can be chosen. The stresses most frequently encountered are direct tension, stress due to acceleration, stress due to sudden or shock loads, stress due to bending, and stress resulting from several forces acting at one time. Strength Wire rope in service is subjected to several kinds of stresses. Ability to withstand distortion and crushing, otherwise known as abuse.Ability to withstand repeated bending without failure of the wire from fatigue.Strength sufficient to take care of the maximum load that may be applied, with a proper safety factor.A proper choice is made by correctly estimating the relative importance of these requirements and selecting a rope which has the qualities best suited to withstand the effects of continued use. ![]() Selecting Wire Rope When selecting a wire rope to give the best service, there are four requirements which should be given consideration. Wires used in these wire ropes are individually coated with a layer of zinc which offers a good measure of protection from corrosive elements. The lower cost is usually a consideration in the selection of galvanized carbon steel. Galvanized Carbon Steel This is used where strength is a prime factor and corrosion resistance is not great enough to require the use of stainless steel. Type 305 is used where non-magnetic properties are required, however, there is a slight loss of strength. Other types frequently used in wire rope are 304, 305, 316 and 321, each having its specific advantage over the other. The 18% chromium, 8% nickel alloy known as type 302 is the most common grade accepted due to both corrosion resistance and high strength. Stainless Steel This is used where corrosion is a prime factor and the cost increase warrants its use. In order to meet these requirements, wire rope is produced in a number of different materials. Materials Different applications for wire rope present varying demands for strength, abrasion and corrosion resistance. The file isn't much bigger than the H.264 files, which is surprising. TMPGEnc looks much better! It's not perfect, but in terms of playback on my PC, it's a lot closer to the source material. ![]() H.264 CBR and VBR have some blocking, but it's not nearly as bad. I looked at these clips several times on my computer. I then exported it in a bunch of different formats: I went ahead and created a 25 second clip where I noticed bad compression. If I don't find a nice exporting format soon, though, I think I will create a small clip and start uploading tests so that I can get feedback. I've been exporting the entire hour-long video each time because I want to get a good "feel" of how long an hour of video takes to process, and how much disk space it will consume. ![]() Question: For the ProRes file, it seems I can either upload the ProRes directly to YouTube (which should be very slow) or compress it to H.264 using Handbrake or something else. I'm now trying TMPGEnc H.264, and then after that I will try ProRes 422 LT. It still adds some blockiness compared to the original GoPro file, but it seems better than the VBR 75-100 Mbps. I suppose this is not surprising, since they're only 40 and 60 Mbps, while my original H.264 test was 70-100 Mbps. The first thing I noticed is that the HEVC (H.265) files have the worst blockiness. I've looked at the exported mp4s from yesterday's tests, focusing on a part of my video which is noticeably "blocky" in the mp4 output. Export to Apple ProRes and use that file in Shutter Encoder/HandBrake. I have not tested and compared all, but Shutter Encoder and HandBrake are both good and free. You can test a free trial version that has no watermarks. I am on Windows and choosed TMPGEnc Movie Plug-in AVC for Premiere Pro so i can export directly from the timeline. If i need H.264 i use a third party encoder. (Hence my recommenation for using Apple ProRes/GoPro CineForm for YT uploads.) Using a higher bitrate won´t solve it either and Adobe seems to ignore the issue or for example add the x.264 codec for pristine exports. It is great for static shots but falls apart quickly for non-static shoths. It fall apart pretty quickly compared to other encoders/codecs.īecause of this issue alone i never use Adobes own H.264 exporter. It has some serious issues when there is fine details and/or lot´s of motion in the image, as you already has encountered. ![]() Another thing to take into consideration is the built in H.264 codec in Premiere Pro. What CBR bit rate do you recommend for 4K 60?īy have not done any testings with 4K but i would start with a minimum of 100. Are there other settings in Premiere Pro I should try? When exporting with Premiere Pro, is a target/max bitrate of 75/100 good for 4K 60fps, or should I go higher? It's already taking multiple days for YouTube to finish the HD processing for my videos, so I haven't tested other bit rates. ![]() How can I decrease the compression artifacts?Īre there settings in the GoPro that can help? I'm using the GoPro's high bit rate setting, and have experimented with different levels of sharpness and other settings, but don't have a feel for which settings work best. So the faster I move, the more artifacts I get. When I am jogging, I get more artifacts than when I am walking. I'm noticing lots of compression artifacts (patches of blurriness) on YouTube, usually on distant trail surfaces, but also sometimes in the underbrush or on distant mountains. I then upload the exported video to YouTube, wait for HD Processing to finish, and view them in my browser on various computers and my 4K TV. I edit the videos in Premiere Pro, and then export them using VBR 2-pass with a target bitrate of 75 and max of 100. It's mostly walks and jogs on trails, nothing really wild in terms of movement. I've been recording 4K 60fps videos on my GoPro. |
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